Razionale scientifico

Principio attivo Quantità (singola compressa) Macro-area di azione Azione biologica Riferimenti bibliografici
D-ribosio 60 mg Efficienza metabolica Incremento del metabolismo energetico, miglioramento del livello di fitness 1, 2
Inositolo 40 mg Efficienza metabolica Riduzione dell’insulino-resistenza 3,4
L-arginina cloridrato 50 mg Benessere cardiovascolare Incremento della sintesi di ossido nitrico 5, 6
Fosfatidilserina 5 mg Performance cognitive Miglioramento dell’umore e della funzione cognitiva 7, 8
Bacopa estratto secco 4:1 70 mg Performance cognitive Azione nootropica 9, 10
Maca radice estratto secco 4:1 25 mg Performance sessuali Incremento della libido 11, 12
Tribulus estratto secco 4:1 50 mg Performance sessuali Incremento della libido 13, 14
Quercetina 40 mg Benessere visivo Prevenzione della cataratta e delle retinopatie 15, 16
Monacolina da riso rosso f. 1 mg Benessere cardiovascolare Effetto ipocolesterolemizzante 17, 18
Berberina 100 mg Benessere cardiovascolare Effetto ipolipemizzante 19, 20
Silimarina da Cardo mariano 40 mg Efficienza metabolica Effetto epatoprotettivo 21, 22

Bibliografia

1.

Mahoney DE, Hiebert JB, Thimmesch A, Pierce JT, Vacek JL, Clancy RL, Sauer AJ, Pierce JD. Understanding D-Ribose and Mitochondrial Function. Adv Biosci Clin Med. 2018;6(1):1-5. doi: 10.7575/aiac.abcmed.v.6n.1p.1

2.

Seifert JG, Brumet A, St Cyr JA. The influence of D-ribose ingestion and fitness level on performance and recovery. J Int Soc Sports Nutr. 2017 Dec 20;14:47. doi: 10.1186/s12970-017-0205-8

3.

Bevilacqua A, Bizzarri M. Inositols in Insulin Signaling and Glucose Metabolism. Int J Endocrinol. 2018 Nov 25;2018:1968450. doi: 10.1155/2018/1968450

4.

Muscogiuri G, Palomba S, Laganà AS, Orio F. Inositols in the Treatment of Insulin-Mediated Diseases. Int J Endocrinol. 2016;2016:3058393. doi: 10.1155/2016/3058393

5.

Wu G, Meininger CJ, McNeal CJ, Bazer FW, Rhoads JM. Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. Adv Exp Med Biol. 2021;1332:167-187. doi: 10.1007/978-3-030-74180-8_10

6.

McRae MP. Therapeutic Benefits of l-Arginine: An Umbrella Review of Meta-analyses. J Chiropr Med. 2016 Sep;15(3):184-9. doi: 10.1016/j.jcm.2016.06.002

7.

Parker A, Gordon J, Thornton A, Lubker J, Bartlett M, Jäger R, Purpura M, Bird M, Oliver J, Simbo S, Rasmussen C, Kreider RB. The effects of phosphatidylserine supplementation on cognitive functioning prior and following an acute bout of resistance training in young males. J Int Soc Sports Nutr. 2010 Sep 15;7(Suppl 1):P2. doi: 10.1186/1550-2783-7-S1-P2

8.

Glade MJ, Smith K. Phosphatidylserine and the human brain. Nutrition. 2015 Jun;31(6):781-6. doi: 10.1016/j.nut.2014.10.014

9.

Aguiar S, Borowski T. Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation Res. 2013 Aug;16(4):313-26. doi: 10.1089/rej.2013.1431

10.

Fatima U, Roy S, Ahmad S, Ali S, Elkady WM, Khan I, Alsaffar RM, Adnan M, Islam A, Hassan MI. Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation. Front Nutr. 2022 Aug 18;9:972379. doi: 10.3389/fnut.2022.972379

11.

Gonzales GF, Córdova A, Vega K, Chung A, Villena A, Góñez C, Castillo S. Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men. Andrologia. 2002 Dec;34(6):367-72. doi: 10.1046/j.1439-0272.2002.00519.x

12.

da Silva Leitão Peres N , Cabrera Parra Bortoluzzi L , Medeiros Marques LL , Formigoni M , Fuchs RHB , Droval AA , Reitz Cardoso FA . Medicinal effects of Peruvian maca (Lepidium meyenii): a review. Food Funct. 2020 Jan 29;11(1):83-92. doi: 10.1039/c9fo02732g

13.

Sirotkin AV, Kolesárová A. Puncture vine (Tribulus Terrestris L.) in control of health and reproduction. Physiol Res. 2021 Dec 30;70(Suppl4):S657-S667. doi: 10.33549/physiolres.934711

14.

Kamenov Z, Fileva S, Kalinov K, Jannini EA. Evaluation of the efficacy and safety of Tribulus terrestris in male sexual dysfunction-A prospective, randomized, double-blind, placebo-controlled clinical trial. Maturitas. 2017 May;99:20-26. doi: 10.1016/j.maturitas.2017.01.011

15.

Zhao L, Wang H, Du X. The therapeutic use of quercetin in ophthalmology: recent applications. Biomed Pharmacother. 2021 May;137:111371. doi: 10.1016/j.biopha.2021.111371

16.

Stefek M, Karasu C. Eye lens in aging and diabetes: effect of quercetin. Rejuvenation Res. 2011 Oct;14(5):525-34. doi: 10.1089/rej.2011.1170

17.

Minoretti P, Biagi M, Emanuele E. An open-label study on the short-term effects of a novel EFSA-compliant nutraceutical combination in mild-to-moderate hypercholesterolemia. Avicenna J Phytomed. 2022 Nov-Dec;12(6):559-565. doi: 10.22038/AJP.2022.20662

18.

Xiong Z, Cao X, Wen Q, Chen Z, Cheng Z, Huang X, Zhang Y, Long C, Zhang Y, Huang Z. An overview of the bioactivity of monacolin K / lovastatin. Food Chem Toxicol. 2019 Sep;131:110585. doi: 10.1016/j.fct.2019.110585

19.

Li YH, Yang P, Kong WJ, Wang YX, Hu CQ, Zuo ZY, Wang YM, Gao H, Gao LM, Feng YC, Du NN, Liu Y, Song DQ, Jiang JD. Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. J Med Chem. 2009 Jan 22;52(2):492-501. doi: 10.1021/jm801157z

20.

Doggrell SA. Berberine–a novel approach to cholesterol lowering. Expert Opin Investig Drugs. 2005 May;14(5):683-5. doi: 10.1517/13543784.14.5.683

21.

Gillessen A, Schmidt HH. Silymarin as Supportive Treatment in Liver Diseases: A Narrative Review. Adv Ther. 2020 Apr;37(4):1279-1301. doi: 10.1007/s12325-020-01251-y.

22.

Wadhwa K, Pahwa R, Kumar M, Kumar S, Sharma PC, Singh G, Verma R, Mittal V, Singh I, Kaushik D, Jeandet P. Mechanistic Insights into the Pharmacological Significance of Silymarin. Molecules. 2022 Aug 21;27(16):5327. doi: 10.3390/molecules27165327.

minofly integratore volo

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